Several digital technologies have emerged to support the management of glucose control, including dose calculations, insulin titration algorithms based on artificial intelligence (AI), and closed-loop insulin delivery systems.14 However, only a limited number of approaches consider the diverse and dynamic characteristics of T2D, and most of them are still in the preclinical simulation phase.15,16 In addition, current solutions were mainly designed for single insulin regimen,17,18 which limits their applications in patients with different treatments. Here, INS is linked to type 2 diabetes mellitus.