The GAL4-NR4A2-dependent transactivation is cell context-dependent and is induced in colon and pancreatic cancer cells [30,33] and decreased in U87MG glioblastoma cells [30], whereas CDIM compounds that bind NR4A2 decrease cell viability in colon, pancreatic cancer and glioblastoma cells [23,24,25,30]. The gene discussed is LGALS4; the disease is familial pancreatic carcinoma.