Recent studies have shown that a series of 1,1-bis(3′-indolyl)-1-(3,5-disubstituedphenyl)methane (DIM-3,5) analogs were identified as NR4A1 ligands that are potent inhibitors of breast cancer growth in an orthotopic athymic nude mouse model with IC50 values for tumor growth inhibition of <1 mg/kg/day [29]. The gene discussed is NR4A1; the disease is neoplasm.