The effects of DIM-3,5-Br2, DIM-3-CI-5-CF3 and DIM-3,5-CI2 on NR4A1- and NR4A2-dependent transactivation were determined in RKO (Figure 3A), SW480 (Figure 3B) and HCT116 (Figure 3C) colon cancer cell lines transfected with GAL4-NR4A1 or GAL4-NR4A2 chimeras and UAS-Luc, which contains five yeast GAL4 response elements. Here, NR4A1 is linked to malignant colon neoplasm.