TP73-AS1 promotes NSCLC progression through multiple molecular pathways: on one hand, TP73-AS1 enhances tumor cell invasion and migration by regulating the expression of miR-21 [12] and promotes tumor cell proliferation by binding to miR-141-3p [49]; on the other hand, TP73-AS1 can also activate the PI3K/Akt signaling pathway to promote tumor proliferation [13]. This evidence concerns the gene AKT1 and neoplasm.