Additionally, newly identified nuclear gene defects can influence the LHON phenotype—notably, a recent study found biallelic mutations in DNAJC30 (a complex I assembly factor) that cause an LHON-like optic neuropathy with a recessive inheritance, illustrating how nuclear genome variation can produce an LHON phenotype by impairing mitochondrial complex I repair [77]. Here, DNAJC30 is linked to Optic neuropathy.