GLP-1/GIP RA class medications are powerful appetite suppressants and with fewer calories consumed, the focus on macro and micronutrients intake becomes even more important, to avoid developing protein-energy malnutrition, nutrient deficiencies and a potential acceleration of bone loss and mental ill health, further aggravated by insufficient vitamin D levels and inadequate calcium intake [87, 88]. This evidence concerns the gene GIP and protein-energy malnutrition.