TIM-3 is also expressed on a variety of cancer cells in solid tumors [151], including melanoma [36, 163, 164], colon carcinoma [165], hepatocellular carcinoma cells (HCC) [166, 167], osteosarcoma [168], and non-small cell lung cancer (NSCLC) [169]. The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.