Although expression of specific ER stress markers (ATF6, GRP78, PERK and IRE1), regulators of UPR (heat shock proteins), some UPS proteins, and autophagy-related proteins have been previously studied in the context of CVD and/or AD [11, 114], no direct link has yet been established between AD and CVD. The gene discussed is EIF2AK3; the disease is Alzheimer disease.