Two protein components of the ubiquitin-proteasomal system (UPS)—ubiquitin-C-terminal hydrolase (UCHL1), a deubiquitinase, and polyubiquitin-B (UBB) —accumulate in post-MI aggregates, contributing to dysfunctional synaptic activity and proteinopathy that arises after cardiovascular disease [57]. The gene discussed is UCHL1; the disease is proteostasis deficiencies.