SYNE1 and Alzheimer disease: Many of the top-ranked proteins had been previously implicated in neurodegeneration; for the AD interactome, these include FILA, PLEC, SYNE1, UBR4, and ANK2; while in the CVD interactome we find NFH_AD, FILA, PLEC, CAC1A, and SPTN4 (Fig. 6A‒C).