It has been reported that NLRP3-inflammasome signalling activation is closely associated with age‐related liver injury and liver fibrosis and that excessive ROS accumulation activates the NLRP3 inflammasome in the liver during the process of aging, eventually leading to aging‐associated liver disease (Gallego et al. 2020; Li et al. 2021). The gene discussed is NLRP3; the disease is age.