While osteoporosis was higher (22.9% vs 12.3%, p = 0.045; OR:4) and asthma/chronic dyspnea (14.1% vs 6.6%, p = 0.07) tended to be higher in patients with p-ANCA/MPO ( +) compared to c-ANCA/PR3 ( +); cataract (6% vs 21.5%, p = 0.003; OR:9.1), hearing loss (2.4% vs 16.7%, p = 0.001; OR:10.5) and nasal septum perforation (2.4% vs 16.2%, p = 0.001; OR:10.2) were lower in p-ANCA/MPO ( +) group (Supplementary Table 1). This evidence concerns the gene MPO and osteoporosis.