DRD2 and Parkinson disease: Defined as pathologic failures to resist urges to perform acts regardless of their negative consequences [8,9], ICBs have been linked to altered ventral striatal D2-like receptor (D2-R) expression and dysregulated mesocorticolimbic DA release, emphasizing the influence of the DA-ergic system in regulating mood in PD [10,11,12,13].