Elevation of the necroptosis molecular effectors p-RIPK3 and p-MLKL following cisplatin exposure is consistent with increased activation of necroptosis, demonstrating that in cell lines with enforced expression of this tumor suppressor that are exposed to chemotherapeutic agents, there was increased activation of this cell death pathway (Figure 5M,N) [35,46]. The gene discussed is MLKL; the disease is neoplasm.