In fibromyalgia induced by ICS, electroacupuncture treatment and TRPV1 deletion decreased IL-17 and IL-17-related signaling pathways (PI3K/Akt, p38, JNK, NF-κB) levels in somatosensory cortex and cerebellum lobe V–VII in female mice and reduced heat and mechanical hyperalgesia [84], indicating the role of IL-17 in electroacupuncture-treated fibromyalgia in females. Here, MAPK8 is linked to fibromyalgia.