In the fibromyalgia model (Table 1), IL-1β in microglia of the medial prefrontal cortex of female rats was increased, and injection of IL-1β antibody significantly reduced the expression of group III secretory phospholipase A2 (sPLA2-III) in neurons, alleviating thermal hyperalgesia and mechanical allodynia in the hind paws [81], indicating that IL-1β-mediated glial-neuron crosstalk contributes to the development of fibromyalgia in females. This evidence concerns the gene IL1B and fibromyalgia.