In cancer-induced bone pain (Table 1 and Figure 2), increased IL-6 in DRG neurons of female rats upregulated expression and activation of TRPV1 through triggering Janus kinase (JAK)/phosphatidylinositol 3-kinase (PI3K) signaling pathway, resulting in mechanical allodynia and thermal hyperalgesia [87]. This evidence concerns the gene IL6 and cancer.