In addition, in MOG35–55-induced MS, an autoimmune inflammatory disorder of the nervous system, increased mechanical and thermal pain responsiveness in MS was paralleled by a significant decrease in plasma membrane calcium ATPase 2 (PMCA2) level in the spinal dorsal horn of female mice, but the PMCA2 level remained unaltered in MS mice without the increased pain [65], indicating that PMCA2 plays an important role in pain processing in MS females [80]. This evidence concerns the gene ATP2B2 and myeloid sarcoma.