Though male mice showed a similar change in PMCA2 level during MS [65], female mutant PMCA2+/− mice were found to be more sensitive to evoked mechanical pain than wild-type controls of the same sex, whereas such a difference was not observed in male PMCA2+/− and PMCA2+/+ mice [80], indicating that the different mechanisms of PMCA2 in MS-associated pain in different sexes. Here, ATP2B2 is linked to myeloid sarcoma.