NID2 and central nervous system cancer: RNA-Seq followed by GO, KEGG, and GSEA analyses showed that NID2 overexpression in glioma cells is accompanied by activation of pathways involved in promoting cell proliferation, endothelial cell proliferation, cell survival, epithelial–mesenchymal cell signaling, cell–cell signaling, ECM organization, cell adhesion, and cell migration (Figure 5E and Figure 8A).