In addition, Agunloye and colleagues [137] investigated the effects of caffeic acid and chlorogenic acid on systolic blood pressure, heart rate, and the activity of key enzymes involved in blood pressure regulation, including ACE, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and arginase, in a model of cyclosporine-induced hypertension [138]. The gene discussed is ACHE; the disease is hypertensive disorder.