Tumor growth was significantly promoted by macrophages in the co-xenograft model compared to that in the PLC/PFR-5 xenograft model (tumor volume: 1, 1270.03 ± 150.05 mm3 vs. 566.75 ± 57.87 mm3), while myristoyl-CM4 treatment inhibited co-xenograft tumor growth (Figure 7A,B). Here, HSPG2 is linked to neoplasm.