Key risk factors for primary melanoma include exposure to ultraviolet (UV) radiation, especially intermittent intense sun exposure and use of tanning beds, fair skin phenotype, the presence of multiple or dysplastic nevi, a family history of melanoma, and certain genetic mutations, such as CDKN2A or BRAF (v-Raf murine sarcoma viral oncogene homolog B1) [2]. The gene discussed is CDKN2A; the disease is melanoma.