Because of high ECM accumulation, studies have attempted to find serum biomarkers of pulmonary fibrosis, such as laminin (LN), type IV collagen (IV), type III procollagen N-terminal peptide (PIIINP), and hyaluronic acid (HA), which display increased levels compared to healthy individuals, and, in the case of hyaluronic acid and PIIINP, are correlated with a worse disease course [35]. The gene discussed is LAMB2; the disease is pulmonary fibrosis.