TP53 and small cell lung carcinoma: For example, the TP53 and RB1 gene mutations are identified as the most common mutations in Chinese patients with SCLC, and other mutations are detected as LRP1B, FAM135B, SPTA1, KMT2D, FAT1, and NOTCH3, emphasizing the ethnicity-dependent mutational profile in Chinese SCLC patients [124].