HSPG2 and osteochondritis dissecans: Several tissue-injury-associated proteins, including tenascin C (TNC), heparan sulfate proteoglycan 2 (HSPG2), and Von Willebrand factor (VWF) [33,34,35], were upregulated in OD versus NOD at the baseline, while selenoprotein P (SELENOP), apolipoprotein A1 (APOA1), and vascular endothelial protection mediators [36] were downregulated (Figure 5f).