This phenomenon has been described in all central nervous system lesions from spinal cord injury, where the “microglial scar” formation is considered to facilitate functional recovery [44], to Alzheimer’s disease (AD), where studies on tau protein have shown that by depleting microglia, the propagation of tau is suppressed [45], once again reflecting the complexity of microglia function. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.