In our work, the combination achieved the best results; high-dose ABZ killed the larvae directly, increased the inflammatory cells, and modulated the PD1 local expression while Silymarin showed anti-inflammatory, antioxidant, and anti-angiogenesis properties in addition to the modulatory action on PD1 expression which enhanced the efficacy of ABZ and created a balanced immune response against the infection with significant reduction of the larval burden, and regression of the resultant myositis. Here, PDCD1 is linked to infection.