In the absence of an effective drug against the muscular phase of trichinellosis, Evaluating the possible anti-Trichinella spiralis efficacy of silymarin (the active ingredient of the milk thistle plant known to have a modulatory action on PDL1 protein) alone or combined with Albendazole (the reference drug) for the first time was the aim of our study. The gene discussed is CD274; the disease is trichinosis.