CDKL5 and craniodiaphyseal dysplasia: To fully understand the mechanisms underlying sleep disturbances and explore the potential utility of sleep and quantitative EEG parameters as functional and therapeutic biomarkers in CDD, animal models that closely recapitulate sleep phenotypes observed in CDD patients are needed, given that in CDD patients, several factors, including intrinsic CDKL5 loss-of-function pathology, secondary impact of seizures, and medication, are implicated in sleep problems and EEG signal alterations [28,29].