In this regard, the eukaryotic initiation factor 4F complex (eIF4F) composed of eIF4E-eIF4G-eIF4A is located at the convergence of several pathways involved in cancer, notably the PI3K/Akt/mTOR and potentially the oncogenic STAT1 that promotes the expression of B-cell lymphoma xl (Bcl-xL) gene [5,6]. The gene discussed is EIF4G1; the disease is cancer.