PDCD4 and neoplasm: The tumor suppressor PDCD4 was slightly upregulated in BT474LapRV1 and BT474LapRV2 cells under Lap and Lap plus Cry treatments, whereas BT474 cells displayed a slight PDCD4 diminution in response to treatments (Figure 4B,C), although PDCD4 levels always remained high in chemoresistant variants.