In contrast, under diabetic circumstances, in acellular capillaries, no changes were detected in the PACAP-treated group (0.75 ± 0.08) than in the diabetes group (4.00 ± 0.27) in the peripheral area, while significance could be observed in the edge region (2.50 ± 0.35 (diabetes) vs. 0.46 ± 0.07 (diabetes + PACAP)) (Figure 6E,F). This evidence concerns the gene ADCYAP1 and diabetes mellitus.