In the 8-week diabetic samples, the fasting glucose level was elevated to 15.43 ± 1.9 mmol/L (diabetes) vs. 5.73 ± 0.15 mmol/L in the control group, and, in the diabetes + PACAP group, to 11.05 ± 1.19 mmol/L, vs. 6 ± 0.27 mmol/L in the control + PACAP group. Here, ADCYAP1 is linked to diabetes mellitus.