In the same scRNA-seq dataset, we also assessed P4HA1 gene expression in PDAC tumor cells enriched in the hypoxia gene signature, further confirming the association of P4HA1 expression and hypoxia (Supplementary Fig. S3A; fold change = 2.073, P = 4.188 × 10−126). Here, P4HA1 is linked to neoplasm.