TNF and psoriasis: The intricate interplay between autophagic cell death and inflammatory pathways is evidenced by multiple studies; Toll-like receptor (TLR)2/6 or TLR4 stimulation activates the autophagic cell death in human keratinocytes [15], while psoriasis-associated cytokines such as TNF-α and IL-17A impair autophagy in these cells [16,17].