For example, Senataxin (SETX) is a 5′→3′ helicase that resolves R-loops, especially during transcription termination; mutations in SETX cause AOA2 (ataxia oculomotor apraxia 2) and ALS4, disorders marked by R-loop accumulation in neurons [46,47]. The gene discussed is SETX; the disease is spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2.