MAP3K5 and cardiac hypertrophy: Savira, F. et al. [35] analyzed whether apoptosis signal-regulated kinase apoptosis kinase 1 (ASK1), a regulator of the cellular response to stress, is involved in cardiac hypertrophy and cardiorenal fibrosis induced by indoxyl sulfate (IS) and p-cresol sulfate (PCS) in vitro, and whether inhibition of ASK1 is beneficial in ameliorating these cellular effects.