Similarly, another study reported that Lut treatment increased Bcl-2 expression while reducing levels of pro-apoptotic proteins, such as Bax, Cyt c, cleaved Caspase-3, and cleaved Caspase-9 in a model of Alzheimer’s disease-induced neuronal apoptosis [69]. This evidence concerns the gene CASP9 and early-onset autosomal dominant Alzheimer disease.