The objectives of this study were the following: (i) to explore whether the IL17 (A7448G and G197A) and TLR4 (Asp299Gly and Thr399Ile) gene polymorphisms act as risk factors for advanced liver fibrosis stages in MASLD patients; (ii) to examine the association between plasma levels of IL17A/F and TLR4, and IL17 (A7448G and G197A) and TLR4 (Asp299Gly and Thr399Ile) gene polymorphisms, stratified by liver fibrosis stages. The gene discussed is IL17A; the disease is Hepatic fibrosis.