GTF2H1 and neoplasm: The allelic loss of chromosome 11 has been shown to be associated with tumor aggressiveness as a consequence of deregulating many genes located in this area, such as the CD44 molecule (CD44), Tumor Susceptibility 101 (TSG101), Diacylglycerol Kinase Zeta (DGKZ), HIV-1 Tat Interactive Protein 2 (HTATIP2), and General Transcription Factor IIH Subunit 1 (GTF2H1) [69].