GH1 and acromegaly: Other germline forms associated with these tumors are (1) neurofibromatosis type 1, with characteristics of acromegaly with an excess of GH and IGF1; (2) tuberous sclerosis, with genetic alterations of Tuberous Sclerosis Protein (TSC) 1 or TSC2 genes that were also found in patients with Pas; (3) germline CABLES1 types, as it has been found that the expression of the CABLES1 protein is lost in more than half of corticotrope adenomas (CAs); and (4) a CDH23 mutation which needs further investigations, as it is still unclear how it can influence the pituitary tumorigenesis [24].