HAMP and inflammatory bowel disease: To elucidate the impact of CB2 receptor stimulation on IBD macrophages’ iron metabolism, we evaluated the effects of JWH-133 [100 nM] and AM630 [10 μM] administration after 48 h of incubation on hepcidin release, and FPN-1 protein expression via ELISA assays and WB, respectively (Figure 5).