Upregulation of SMases was shown to be associated with several malignancies, including glioblastoma, colon and ovarian cancers and non-small cell lung cancer (NSCLC), conferring resistance against both chemotherapy and radiotherapy [15].Overexpression of acidic sphingomyelinases aSMase in glioblastoma cells leads to higher sensitivity to gemcitabine and doxorubicin therapy, due to elevated ceramide levels promoting apoptosis [49]. This evidence concerns the gene SMPD1 and glioblastoma.