- sRAGE protected against liver fibrosis- In pigs, RAGE antagonism and sRAGE decreased lung inflammation - sRAGE inhibits I/R-induced apoptosis, both in the hearts of mice and cardiomyocytes- RAGE administration prevented renal tubular damage in models of ischemia/reperfusion-induced AKI- sRAGE effectively lessened microcirculation impairment and vascular injury after SAH- Empagliflozin reduced the AGE–RAGE-oxidative stress- induced inflammatory reactions in the adipose tissues of db/db mice. This evidence concerns the gene AGER and ischemia.