In current study, the enhanced expression of PRDX2 and PRDX5 was noticed in the ipsilateral hemisphere 24 h after stroke onset, which may suggest the pro-inflammatory role of those two PRDXs after ischemia, which is consistent with Shichita et al.’s study where PRDX blocking in mice resulted in a better outcome after stroke and was associated with the reduction in cells producing inflammatory mediators [32,33]. This evidence concerns the gene PRDX5 and stroke disorder.