RHOA and small cell lung carcinoma: Specifically, in the SCLC environment, there was an up-regulation of pathways including the abnormal electron transport chain activity of TDP43 protein due to mutation in complex I, the degradation of abnormal Aβ protein via the 26S proteasome-mediated pathway, forward axonal transport, Escherichia coli ESPG to microtubule RhoA signaling, and mismatch repair pathways caused by mutations.