Interestingly, two genes from this family (KCNJ15 and KCNB1) that were up-regulated by the fluorinated chalcone in this study have previously been reported to be down-regulated in several human cancers [38,39,40], which further strengthens this hypothesis regarding the role of these genes in the induction of apoptosis, the inhibition of cell proliferation, and migration. The gene discussed is KCNB1; the disease is cancer.