(4) The fluorinated chalcone promotes the degradation of proteins involved in cell proliferation and metastasis via the proteasome system. This is based on the fact that our bioinformatics analysis identified several up-regulated KLHL genes, which have been reported to play important roles in ubiquitination processes by interacting as substrates in the Cullin3 (Cul3) ubiquitin ligase complexes to promote the degradation of proteins involved in tumor progression [76,77]. The gene discussed is CUL3; the disease is neoplasm.