KLHL25 and B-cell chronic lymphocytic leukemia: Among the genes belonging to this family, KLHL25, KLHL3, and KLHL6 were found to be up-regulated by the fluorinated chalcone; curiously, these genes have been described to inhibit cell migration and invasiveness in lung carcinoma [76], diffuse large B-cell lymphoma [79], and chronic lymphocytic leukemia [80].