HSF1 and neoplasm: It is of great interest to mention that, in the HSF1-dependent transactivation pathway, TAD is a fundamental component for the survival of breast cancer cells once they have been subjected to conditions of stress or cell death, as it drives transcriptional programs of non-canonical genes involved in multiple aspects of tumorigenesis, such as apoptosis inhibition, reprogramming of cell metabolism, angiogenesis, adjustment of the tumor microenvironment, proliferation, cell migration, and metastasis [92,95].