APOE and osteosarcoma: Other genes found to be up-regulated in our study that support this assumption were SLC1A3, SLC16A1, LINC00426, LINC01234, LINC02577, MAFB, APOE, MMP3, APOH, and CETP, which have been associated with increased chemoresistance in pancreatic carcinoma [83,84], osteosarcoma [85], breast carcinoma [86], multiple myeloma [87], and hepatocellular carcinoma [88].