Upon confirmation of retinal degeneration in Chm-cKO mice (Figure S1A), resembling the retinal phenotype observed in Chm+/− female mice [6], we set out to examine the impact of REP-1 beyond the ocular system, with a focus on systemic metabolism, because a recent study has shown significant metabolic alterations in individuals with choroideremia [10]. Here, CHM is linked to retinal degeneration.