Research aimed at investigating the relationship between systemic immune inflammation status, as indicated by inflammatory biomarkers (PTX3, hs-CRP, TNF-α, and IL-6) or established hematological markers (NLR, MLR, PLR, AISI, SII) alongside novel markers, specifically MCVL and IIC, and obesity (various obesity-related indices) in patients with PreDM and newly diagnosed T2DM, as documented in both the international and Romanian specialized literature, remains scarce. This evidence concerns the gene PTX3 and type 2 diabetes mellitus.