Our study aimed to evaluate, through the analysis of the ROC curve, whether the investigated parameters (PTX3, hs-CRP, TNF-α, IL-6, NLR, MLR, PLR, AISI, SII, MCVL, and IIC) can distinguish the inflammatory status in PreDM and T2DM patients. This evidence concerns the gene PTX3 and type 2 diabetes mellitus.