Research aimed at investigating the relationship between systemic immune inflammation status, as indicated by inflammatory biomarkers (PTX3, hs-CRP, TNF-α, and IL-6) or established hematological markers (NLR, MLR, PLR, AISI, SII) alongside novel markers, specifically MCVL and IIC, and obesity (various obesity-related indices) in patients with PreDM and newly diagnosed T2DM, as documented in both the international and Romanian specialized literature, remains scarce. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.