F2 and hemangioma: Prothrombin levels decrease with the consumption of prothrombin by the accelerated coagulation–fibrinolysis within hemangiomas that results in a compensatory increased production of prothrombin precursors in hepatic cells, which leads to increased demand for vitamin K or γ-glutamyl carboxylase, and causes a deficiency in vitamin K and a subsequent decrease in γ-glutamyl carboxylase activity.