APP and early-onset autosomal dominant Alzheimer disease: These qualitative findings are consistent with the literature [20,22,23,42], which describes the 3xTg-AD model as widely used for studying Alzheimer’s disease due to mutations in the APP, PS1, and Tau genes, which allow the formation of characteristic lesions such as Aβ deposits and hyperphosphorylated Tau neurofibrillary tangles [43].