It should also be noted that iron overload in subjects with SCD is linked to the iron released by sRBCs, to chronic transfusions that cause an imbalance in iron homeostasis and potentially to an alteration of iron metabolism, conditions that lead to an imbalance of hepcidin [56]; in addition, studies in the literature show that individuals with SCD may experience iron overload due to chronic transfusions [57]. Here, HAMP is linked to Tangier disease.