Notably, some studies considered very high titers of anti-TTG IgA antibodies (in general, 10x the upper limit of normality) as a direct diagnosis of celiac disease, without the need for EDA with duodenal biopsy, as recommended by the European guidelines mentioned above.18,25,27,36 Other studies required diagnostic confirmation by biopsy, regardless of previous IgA anti-TTG antibody values. Here, CD79A is linked to celiac disease.