Regarding the other TRP channel with high expression in prostate cancer, TRPM4, prostate cancers with high mean mRNA expression in the MSK cohort, defined as a z score compared to normal samples above 1.5 (n = 42, 28%), did not differ from cancers with low TRPM4 mRNA expression in the presence of aneuploidy or the presence of ERG fusions, as measured by either aCGH (array Comparative Genomic Hybridization) or gene expression (Table 5). This evidence concerns the gene TRPM4 and Familial prostate cancer.