At the mRNA level, the TRP channel that was most over-expressed in prostate cancer in the MSK cohort compared with a normal prostate was MCOLN2 (mean mRNA expression z score compared to normal samples = 2, SD = 2.01, t test compared with the second most expressed channel TRPV1 p = 0.0001, Figure 2); TRPM4, TRPM1, TRPM8 and MCOLN1 were also over-expressed, although at lower average levels. This evidence concerns the gene TRPM8 and Familial prostate cancer.