TRPM4 and Familial prostate cancer: Although prostate cancers with lower Gleason scores of 6 or 7 were dominant in both groups, the group with high mean TRPM4 mRNA expression displayed a higher frequency of Gleason score 6 and 7 cancers (94.9%), while only 80% of cancers with low TRPM4 mRNA expression had Gleason scores of 6 or 7 (Fisher’s exact test p = 0.03, Table 4).