F8 and autoimmune hemolytic anemia: Typically, AHA diagnosis is suspected when patients present acute or recent bleeding symptoms, without a previous history of bleeding, with laboratory data presenting an isolated prolonged APTT, reduced FVIII activity (<1% in 50% of cases; <5% in 75% of cases; <40% in 100% of cases), and the presence of autoantibodies, detected by the Bethesda assay.