Partial 5-HT4R agonist RS-67333 (1 mg/kg, i.p.)exerted anxiolytic effects and ameliorated short-term (3-min) and long-term (24-h) memory deficits in a mouse model of schizophrenia-like cognitive impairment induced by sub-chronic phencyclidine (sPCP) but did not enhance memory in healthy mice. The gene discussed is HTR4; the disease is schizophrenia.