HTR4 and Cognitive impairment: Additionally, we investigated how the 5-HT4R agonist RS-67333—recognized for its memory-enhancing properties [1,5,9,10,12]—modulates circuit dynamics between the CA1 region of the dorsal hippocampus (dHPC) and the prelimbic (PL) mPFC in both healthy mice and a schizophrenia-related cognitive impairment model induced by sub-chronic phencyclidine (PCP) treatment [32,33].