For example, MARK1 and MARK2 are implicated in the development of neurodegenerative diseases such as Alzheimer’s disease through phosphorylation of Tau, which leads to a detachment of Tau from microtubules and therefore to microtubule breakdown, disruption of the axonal transport, and Tau aggregation [16]. The gene discussed is MARK1; the disease is early-onset autosomal dominant Alzheimer disease.