Regarding endocrine, nutritional, or metabolic diseases, type II diabetes (OR = 1.05; 95% CI: 1.01–1.09; p = 0.014), insulin resistance (based on the “gold standard” measurement) (OR = 1.01; 95% CI: 1.00–1.03; p = 0.049), and insulin resistance (based on fasting insulin) (OR = 1.13; 95% CI: 1.04–1.23; p = 0.004) demonstrated positive genetic associations with AD (Figure 2A and Figure A9). Here, INS is linked to Other metabolic disease.