MMP-9 is the most prevalent MMP member, ubiquitously expressed and released in brain and cerebrospinal fluid (CSF) of patients suffering from ischemic stroke, vascular dementia, AD, dolichoectasia, viral-associated neurocognitive disorders, neuro-Behcet’s disease and MS [311,312,313,314]. This evidence concerns the gene MMP9 and myeloid sarcoma.