In this study, we demonstrated for the first time that by silencing thalamic CMT CaV3.1 T-channels, we can modulate fear expression, thus suggesting that CaV3.1 T-channels could be a potential cellular target for disorders where there is an altered fear response such as post-traumatic stress disorder, schizophrenia, anxiety, or substance abuse. The gene discussed is CACNA1G; the disease is post-traumatic stress disorder.